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“Antibiotic resistance is usually associated with a fitness cost” is frequently accepted as common knowledge in the field of infectious diseases. However, with the advances in high‐throughput DNA sequencing that allows for a comprehensive analysis of bacterial pathogenesis at the genome scale, including antibiotic resistance genes, it appears that this paradigm might not be as solid as previously thought. Recent studies indicate that antibiotic resistance is able to enhance bacterial fitness in vivo with a concomitant increase in virulence during infections. (...) As a consequence, strategies to minimize antibiotic resistance turn out to be not as simple as initially believed. Indeed, decreased antibiotic use may not be sufficient to let susceptible strains outcompete the resistant ones. Here, we put in perspective these findings and review alternative approaches, such as preventive and therapeutic anti‐bacterial immunotherapies that have the potential to by‐pass the classic antibiotics. (shrink)

EDITOR’S NOTE: Business Ethics Quarterly invited a number of scholars involved with BEQ over its first twenty years (especially in its early years, as editors or editorial board members) to offer their reflections on the past, present, and future of business ethics. The resulting comments, which appear below, are as diverse and eclectic as the group of scholars who have given their energies to BEQ over the years.

As with the problem of universals, late medieval thinkers were very concerned with the ontological status of relations, for they were central to numerous theological and philosophical problems. These relations were of various types: relations of identity, qualitative similarity, quantitative equality, causal relations, and intentional relations, such as those between knower and the object known. Each of these relations was taken to be an Aristotelian accident. Does it differ from the substance which is related? Broadly speaking, I have discovered four (...) alternative theories: as sentence of the form "a is related by a real relation R to b" is true only if the relation R is an extra-mental thing really distinct from a and b ; R only exists as a concept in a mind ; a and b exist in a certain real way ; the term "R" is connotative, signifying a directly and connoting b . Using printed sources and my critical edition of various codices, I ask the following thinkers whether a real relation is distinct from that which is related: Thomas Aquinas, Giles of Rome, Henry of Ghent, Richard of Middleton, John Duns Scotus, Henry of Harclay, Hervaeus Natalis, and Peter Aurioli. (shrink)

Little is in print on the development in Britain of university disciplines including the academic study of education. This paper provides a historical narrative of the study of adolescence from the 1870 Education Act to the contemporary day. Adolescence textbooks are examined in the context of changes in the education system, such as the demand for secondary education and the expansion of teacher education. Changing emphases in adolescence research are traced through various publications to illustrate curriculum developments. The important contributions (...) of Dame Olive Wheeler, Professor W. D. Wall and other leading writers on adolescence are evaluated. It is clear that in over a century of national educational provision British teachers have never faced a great choice of adolescence texts and the paper concludes with some reflections on this observation. (shrink)

Nicholas of Cusa (1401-1464) was active during the Renaissance, developing adventurous ideas even while serving as a churchman. The religious issues with which he engaged - spiritual, apocalyptic and institutional - were to play out in the Reformation. These essays reflect the interests of Cusanus but also those of Gerald Christianson, who has studied church history, the Renaissance and the Reformation. The book places Nicholas into his times but also looks at his later reception. The first part addresses institutional (...) issues, including Schism, conciliarism, indulgences and the possibility of dialogue with Muslims. The second treats theological and philosophical themes, including nominalism, time, faith, religious metaphor, and prediction of the end times. (shrink)